Adverse reactions of Pelargonium sidoides:
The active compound in umckaloabo or Pelargonium sidoides showed few adverse effects, and those that occurred were at similar rates in both treatment and placebo groups in the above mentioned studies (1-3). Polyphenols and coumarins present in the supplement were studied for increased risk of bleeding. There was no change seen in thromboplastin time (TPT), partial TPT (PTPT) or thrombin time (TT) in rats given extremely large doses of EPs 7630. Also, the supplement added to warfarin treatment did not affect the lab values either. Hemorrhage caused by this agent was felt to be unlikely by the author of the study. (4)