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Age-Related Macular Degeneration
A systematic review on antioxidants and age related macular degeneration (AMD):
A systematic review by Kansagara D et al evaluated seven randomized controlled trials which studied nutritional supplements in patients with AMD. The authors believed that studies with the longest duration and largest group of subjects were able to better identify benefit of the antioxidants because AMD occurs slowly. The smaller studies might have been of insufficient duration or power to detect a treatment effect. The author reinforced that antioxidants prevented functional vision loss in the Age Related Eye Disease Study (AREDS) and that lutein, zeaxanthin, B vitamins, and omega-3 fatty acids have been reported to decrease AMD progression, while vitamin E and β-carotene where found to increase the risk of late AMD. (2)
