Alpha Lipoic Acid (ALA) Adverse Reactions and Interactions:
Participants in the study by Ziegler D et al experienced increasing symptoms of nausea, vomiting, and vertigo as the dose of ALA was increased from 600 mg to 1200 mg to 1800 mg per day.
Assessment and Plan: Alpha Lipoic Acid
- An Alpha lipoic acid (ALA) supplement under a physician’s direction may be an option to treat peripheral neuropathy in diabetes patients. A dose of 600 mg oral once per day was given over 5 weeks and provides the best risk to benefit ratio given side effects according to the study by Ziegler D et al (1). ALA has not been studied long term. Nausea, vomiting, and vertigo occurred as the dose of ALA was increased from 600 mg to 1200 mg to 1800 mg per day (1). Intravenous ALA is available and may be effective but is not practical given cost and ability to treat with oral treatment.
- Alpha lipoic acid levels necessary for treatment of peripheral neuropathy are not possible with intake of ALA from food sources. Alpha lipoic acid (ALA) containing foods include broccoli, spinach, collard greens, citrus, rice bran, tomatoes, and potatoes.
- More research is required before ALA supplements can be recommended for improving insulin sensitivity, treating Alzheimer’s disease or to treat signs of skin aging.