Andrographis paniculata (AP adverse reactions and interactions:
Andrographis paniculata (AP) is well tolerated, but has been found to produce several adverse reactions and interactions.
AP caused gastric irritation and nausea in one patient during a trial for diabetes. (8)
Hypoglycemia (low blood sugar) occurred when using AP as a favorable effect for treatment of diabetes as mentioned above (8). Hypoglycemia also occurred in another study that used much higher doses. A water solution of the plant extract Andrographis paniculata (AP) weas examined for blood sugar lowering effect in rats with normal and high blood sugar levels. Researchers found AP at a dose of 50 mg/kg significantly reduced blood sugar by 52.9%. When a sample of freeze-dried (instead of water solution) extract was used at a dose of 6.25 mg/kg, blood sugar was lowered by 61.81%. (9)