Andrographis paniculata has been shown to relax uterine smooth muscle and therefore should not be taken in pregnancy. (11)
In males, sperm count, motility, and morphology was improved with AP. Testosterone levels were increased with doses of 50 to 200 mg per kilogram in male rats. (10)
Andrographolide has been found to reduce platelet aggregation by inhibiting platelet activating factor, an effect which increased as higher doses were given. This mechanism differed from the mechanism by non-steroidal anti-inflammatory drugs. (12)
A phase I study of AP among 18 individuals (13 confirmed HIV-positive) was stopped after 6 weeks because of multiple cases of reported side-effects such as allergic reactions, fatigue, headache, painful lymphadenopathy, nausea, and diarrhea in doses of 20 mg per kg per day. One major side effect experienced by users of AP as an herbal remedy for minor disorders includes stomach irritation. Other side effects associated with the digestive system include bloating, nausea, vomiting and diarrhea. (13)