Andrographis paniculata and ulcerative colitis:
Andrographis paniculata extract, HPML-004 at a dose of 1200 mg/day may be an effective alternative treatment to the drug mesalazine (4500 mg/day) for mild-to-moderate active ulcerative colitis (UC), a form of inflammatory bowel dieses that causes ulcers in the lining of the rectum and colon. At the end of this 8-week study, 21% of HPML-004 treated participants had clinical remission of UC and 76% had clinical response. Corresponding values in the mesalazine group were 16% and 82%, respectively. Colonoscopy results showed a 28% remission and 74% response rate for HMPL-004, compared to 24% and 71% for mesalazine. No significant difference was apparent between the HPML-004 and the mezalazine groups. (15)