Flavonoid treatment for chronic venous insufficiency, and venous ulcers:
Flavonoid agent for chronic venous insufficiency (CVI): In two randomized, double-blind, 2-month studies, Daflon 500 mg twice daily significantly decreased ankle and calf circumferences, discomfort (nocturnal cramps and sensations of leg heaviness, swelling, or heat), and plethysmographic parameters (measures of changes in volume in organs or the body), such as venous capacitance, distensibility, and emptying in patients with CVI. More leg ulcers (<11 cm in diameter) were completely healed with Daflon 500 mg 2 times per day (plus standard care of compression treatment) for 2-6 months compared to placebo or standard care alone. (1)