Natural extract used for venous hypertensive microangiopathy : Twenty-two individuals with venous hypertensive microangiopathy (VHM, high pressure in the veins) were included in this randomized, placebo-controlled study investigating the benefits of Essaven gel (EG). Results show that compared with placebo, EG significantly improved microcirculation in patients with VHM, even with a single application. (12)
A natural combination treatment for chronic venous insufficiency (CVI):
A double-blind, placebo-controlled trial for plant extract, vitamin, and flavonoid combination for chronic venous insufficiency (CVI): A venotropic agent containing (per capsule)16.5 mg Ruscus aculeatus, an evergreen shrub otherwise known as butcher’s broom (RAES), 75 mg hesperidin, and 50 mg ascorbic acid was found to be better than a placebo for treating chronic venous insufficiency (CVI) of the lower limbs in this double-blind trial (n=40). The trial involved 2 periods of treatment lasting 2 months with participants receiving 2 capsules or placebo administered 3 times daily. Symptoms and measures of plethysmograph circulatory capacity was significantly better in response to RAES treatment. RAES was also well tolerated. (13)