A meta-analysis for a plant extract, vitamin, and flavonoid combination for chronic venous insufficiency (CVI):
Cyclo 3 Fort in the treatment of chronic venous insufficiency: In a meta-analysis of 25 studies (n=10,246) of patients with chronic venous insufficiency (CVI), Cyclo 3 Fort (each capsule contains 150 mg Ruscus aculeatus, 150 mg hesperidin methyl chalcone, and 100 mg ascorbic acid) was found to be superior to placebo. Compared to placebo, Cyclo 3 Fort significantly reduced severity of pain (0.44 points on 4 point scale), cramps (0.26 points), heaviness (0.53 points), paraesthesia or tingling/burning/numbness of a person’s skin (0.29 points), and venous capacity (0.70 ml/100 ml). Swelling (edema), calf and ankle circumference were also significantly better among patients receiving Cyclo 3 Fort versus placebo. (14)