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Chronic Venous Insufficiency, Thrombophlebitis, and Varicose Veins
Pycnogenol vs. Venostasin (horse chestnut seed extract) for chronic venous insufficiency (CVI): A 4-week study compared Venostasin (horse chestnut seed extract) at 600 mg oral daily against Pycnogenol (pine bark extract) at 360 mg oral daily both treated groups showed improvement, but Pycnogenol was more effective for CVI and improved the lipid profile over Venostatin (9).
Essaven gel (EG) used for superficial vein thrombosis and venous hypertensive microangiopathy:
For superficial vein thrombosis: Authors investigated the effect of Essaven gel (EG) with the active ingredient, aescin, (or escin) a horse chesnut extract in comparison with placebo over 8-weeks which found that reductions in the signs and symptoms of SVT were significantly greater in the EG treatment group and no serious side-effects were reported (11).
For venous hypertensive microangiopathy : A randomized, placebo-controlled study with Essaven gel (EG) showed that compared with placebo, EG significantly improved microcirculation in patients with VHM, even with a single application (12).
Ruscus aculeatus (extract of an evergreen shrub also known as butcher’s broom), hesperidin (citrus flavonoid), and ascorbic acid (vitamin C) combination for the treatment of chronic venous insufficiency (CVI):
A double-blind, placebo-controlled trial using 16.5 mg Ruscus aculeatus, 75 mg hesperidin, and 50 mg ascorbic acid, 2 capsules or placebo administered 3 times daily was better than a placebo for treating CVI in both symptoms and measures of plethysmograph circulatory capacity, and treatment was well tolerated (13).
Cyclo 3 Fort (each capsule contains 150 mg Ruscus aculeatus, 150 mg hesperidin methyl chalcone, and 100 mg ascorbic acid) was found to be superior to placebo in reducing severity of pain, cramps, heaviness, paraesthesias, swelling, and leg circumference (14).
Endotelon®, (A brand name product produced from grapeseed containing Procyanidolic Oligomers, Sanofi-Labaz Laboratories, Sanofi Winthrop) used for chronic venous insufficiency: 50 females were treated with either Endotelon® dosed at 150 mg per day or diosmine (semi-synthetic flavonoid) dosed at 450mg per day for 30 days. Endotelon faired better than diosmine for heaviness, sluggishness, cramps and swelling with 65% of the patients responding to Endotelon vs. 45% for diosmine with 15 days of extended treatment effect (15).
