References:
1.Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers, and hemorrhoids. Drugs. 2003;63(1):71-100. http://www.ncbi.nlm.nih.gov/pubmed/12487623
2.Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind randomized, controlled versus placebo trial in 107 patients. Angiology. 1997;48:77-85. http://www.ncbi.nlm.nih.gov/pubmed/8995348
3.Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012 Nov 14;11:CD003230. http://www.ncbi.nlm.nih.gov/pubmed/23152216