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Cranberry, Cranberry Juice Adverse Reactions and Interactions
Cranberry juice taken with warfarin was found to be associated with an increased blood thinning effect in a 78-year-old man taking 45 mg per week of warfarin to maintain a therapeutic PTINR prothrombin time international normalized ratio (PTINR)for irregular heartbeat. A week after drinking half a gallon of cranberry-apple juice, the patient had a PTINR of 6.45—signaling the level had become supratherapeutic. Cranberry juice intake was stopped and warfarin at 40 mg per week was taken. After 5 days, the INR returned back to an acceptable range between 2.0-3.0. (2)
A case revealed an additional circumstance in which a 46 year old female on warfarin drank cranberry juice for several days resulting in elevation of prothrombin time on 2 separate occasions with cranberry juice as the only dietary change (3).
