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Garcinia cambogia
A 2-week laboratory study of fat cells from obese women found that low dose HCA-SX, a weight loss product containing hydroxycitric acid (HCA, derived from the Garcinia cambogia fruit) may induce lipolysis or the breakdown of fats/lipids. Additionally, HCA-SX had a positive effect on leptin, a molecule responsible for appetite regulation and metabolism. (2)
Mattes RD reported in a double-blind placebo controlled randomized trial that Garcinia cambogia (2.4 g/d, containing 1.2 g/day hydroxycitric acid) administered to overweight women (restricted to a 5020 kJ diet) had no effect on food intake or appetite suppression in a 12-week study. However, women taking G. cambogia (n=42) or placebo (n=47) both reported weight loss, though those taking G. cambogia had significantly greater weight loss (3.7 kg vs 2.4 kg). The study supports that weight loss did not occur by appetite suppression. (3)