Resveratrol adverse reactions and interactions:
Resveratrol may worsen atherosclerosis. Atherosclerosis results in arterial wall thickening as a result of the accumulation of fatty materials such as cholesterol. Resveratrol inhibits platelet activation and has anti-inflammatory properties, but paradoxically, it promotes atherosclerosis in rabbits with hypercholesterolemia. The effects of resveratrol were examined on the development of atherosclerotic in rabbits fed 0.5% cholesterol. At the end of the 60-day study period, all rabbits (fed or not fed cholesterol) had similar liver function and had hypercholesterolemia or high levels of cholesterol in the blood. However, compared to the control group, resveratrol-treated rabbits had an increase in atherosclerotic lesions (p<0.002). This suggests that resveratrol results in atherosclerotic development, rather than protecting against it. (13)