Resveratrol has multiple toxicities at high doses. Researchers administered rats dosage of 0, 300, 1000, and 3000 mg/kg of body weight per day of trans-resveratrol for 4 weeks. Administration of 3000 mg/kg/daily resulted in the most reported adverse events: reduced final body weights and food consumption; elevated BUN, creatinine, alkaline phosphatase, alanine aminotransferase, total bilirubin, and albumin; reduced hemoglobin, hematocrit, and red cell counts; and increased white cell counts. Renal (kidney) lesions were also observed as well as increased liver weights among females. Administration of 1000 mg/kg/daily resulted in reduced body weight gain (females only) and elevated white blood cell count (males only). No adverse or side effects were observed at 300 mg resveratrol per kilogram body weight per day in rats. (14)
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