Resveratrol

Resveratrol and multiple myeloma:

Bhardwaj, A et al looked to determine whether resveratrol can suppress cell growth in-vitro of multiple myeloma (cancer that starts in the plasma cells in bone marrow). Resveratrol inhibited the growth of multiple myeloma cells regardless of sensitivity or resistance to conventional chemotherapy agents. It also increased the apoptotic (cell death) effects of the targeted cancer drugs, bortezomib and thalidomide. Resveratrol decreased growth of cancer cells and genes that inhibit apoptosis (such as cyclin D1, cIAP-2, XIAP, survivin, Bcl-2, Bcl-xL, Bfl-1/A1, and TRAF2). These effects are able to occur through interruption of active NF-κB (plays pivotal roles in inflammatory responses and immunological reactions). Resveratrol also inhibited activation of STAT3 (plays a key role in many cellular processes such as cell growth and apoptosis pathways). The authors conclude that resveratrol may have a potential role in the treatment of multiple myeloma. (3)