Riboflavin, Vitamin B2

Riboflavin and efficacy for migraines in children was evaluated by MacLennan SC et al in a randomized, double-blind study. The study performed with a group of 48 children suggested that riboflavin, also known as vitamin B2, is not an effective treatment for migraine headaches. For 4 weeks, participants received either 200 mg/day of riboflavin or placebo. At the end of the study, a reduction by at least 50% in the number of migraine headaches was reported in about 44% of treatment participants and 67% in the placebo group. (2)

Riboflavin and migraines in pregnancy:

Women suffering from migraine headaches during pregnancy may benefit from riboflavin and is considered safe during pregnancy for the treatment of migraine headaches. Of note, magnesium is likely the best choice since it is the only agent with a category-A pregnancy rating, and is therefore an appropriate choice for women who are pregnant or trying to conceive. (3)