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Valerian adverse effects and interactions:
Valerian may have additive effects of sedation to alcohol, antihistamines, muscle relaxants, sedatives, anti-seizure drugs, narcotics, and drugs used in treatment of mental illnesses. In some patients, valerian has made anxiety or insomnia worse or has led to am sluggishness. One should not operate machinery after taking this herb. High doses should be avoided. Valerian may lead to additive sedation and central nervous system depression effects when taken with opioid or narcotic analgesics (2). Use of central nervous system depressant drugs should be avoided when also taking valerian. (3)
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