Flavonoid agent for healing venous leg ulcers: In a multi-center, randomized, parallel-group, double-blind, placebo-controlled trial of 105 patients with venous leg ulcers, using conventional therapy (standardized local treatment with compression therapy) with either Daflon 500 mg (two tablets/day=1 g/day) or placebo (1 g/day) during an 8-week period, complete healing of ulcers ( <10 cm) was significantly higher in the Daflon 500 mg group (32%) compared with placebo (13%). Time to complete ulcer healing was also significantly shorter in the Daflon 500 mg group. (2)
A tree nut used for chronic venous insufficiency:
Tree nut used as anti-inflammatory for chronic venous insufficiency (CVI): Research suggests that horse chestnut seed extract (HCSE), found to have anti-inflammatory effects. In a systematic review researchers analyzed seven clinical trials and concluded that horse chestnut seed extract is an effective and safe treatment for CVI. Compared to placebo, HCSE was associated with significant reduction in leg pain in six studies. Leg volume (associated with swelling caused by CVI) was also reported to be better in the HCSE group compared to placebo (average difference 32.1 ml). One study showed HCSE to be as effective as compression stockings. No serious side-effects were reported. (3)