Curcumin and familial adenomatous polyposis: The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in 5 patients with familial adenomatous polyposis without much toxicity. Patients received curcumin 480 mg and quercetin 20 mg orally 3 times a day. The number and size of polyps were assessed at baseline and after therapy. All 5 patients had a decreased polyp number and size from baseline after a mean of 6 months of treatment with curcumin and quercetin. The mean percent decrease in the number and size of polyps from baseline was 60.4% and 50.9%, respectively. Minimal adverse side effects and no laboratory abnormalities were noted. (6)
