Bio-identical hormones and endometrial cancer:
Three cases of endometrial cancer were reported by Eden, JA et al in women taking troches containing compounded “bio-identical” hormones. Two of the patients were taking commonly used doses of compounded estrogen, progesterone, and dehydroepiandrosterone (DHEA). The third patient was taking testosterone in addition to the other hormones mentioned. (11)
Progesterone vs. Synthetic Progestins:
According to Holtorf (19), women taking progesterone as part of their hormone replacement expressed a greater satisfaction than those on synthetic progestins. This author expressed that the data reviewed on women taking progesterone showed less risk of breast cancer and may avoid negative heart disease related events compared to synthetic progestins.