Contraindications for the use of hormone replacement therapy:
The FDA states that hormone replacement therapy should not be used in abnormal bleeding of the genital area, patients with breast cancer in the past or present, suspected breast cancer, neoplasia suspected or known to be related to estrogen, present or past pulmonary embolism or deep venous thrombosis, myocardial infarction or stroke currently or within the past year, liver disease or elevated liver function tests, allergy to any ingredients, and current or possible pregnancy. (12)
Adverse effects of hormone replacement therapy:
The FDA has published the adverse effects of hormone replacement therapy which may include uterine cancer , breast cancer, ovarian cancer, stroke, myocardial infarction, pulmonary embolism, deep venous thrombosis, dementia, gallbladder problems, painful breasts, abnormal mammogram, abnormal vaginal bleeding, loss of hair, abdominal pain, nausea, and vomiting (3). Avoid exposure of estrogen to children and pets as breast and nipple enlargement has been reported.