Supplements for future breast cancer treatment:
Supplements with in vitro evidence may have future applications in preventing breast cancer.
Curcumin and breast cancer:
Bayet-Robert M, et al performed a phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer was performed in 14 patients. Curcumin was started at a dose of 500 mg per day which was increased as tolerated until toxicity occureed. Toxicity limiting the dose to 8,000 mg per day was determined by the authors and as a result the recommended dose was 6000 mg per day for 7 days every 3 weeks combined with docetaxel was suggested. Most patients showed improvement and the author believed that 50% of patients would be expected to respond and expressed that a phase II trial should be implemented (26).