Coenzyme Q10 and vascular endothelial function:
Endothelial dysfunction occurs after a substance acts upon the endothelium (inner lining) of blood vessels to cause and imbalance of contraction and dilation. Endothelial dysfunction is associated with atherosclerosis, diabetes, hypertension, and cardiovascular disease. A meta-analysis examining the results of five randomized controlled trials, including 194 subjects, found that supplemental coenzyme Q10 (CoQ10) resulted in a clinically significant, 1.7% increase in flow-dependent endothelial-mediated dilation. These findings suggest CoQ10 supplementation is associated with significant endothelial function improvement and provides evidence for use in patients with endothelial dysfunction. (28)