Coenzyme Q10 and dementia:
Coenzyme Q10 and Alzheimer’s dementia:
In a randomized, double-blind, multi-center human study, 450 patients with mild to moderate dementia were given either placebo for 12 months, followed by 90 mg idebenone (a synthetic form of Coenzyme Q10) three times per day for another 12 months; 90 mg three times per day for 24 months; or 120 mg three times per day for 24 months. Significant dose-dependent improvements were seen in measurements of clinical cognitive status and tests (including the Alzheimer’s Disease Assessment Scale [ADAS-Total], ADAS cognitive and noncognitive score, the clinical global response) compared to placebo. In other words, as the dose of idebenone increase so did the benefits. These improvements continued over the 2-year study. (24)