Small study on effects of coenzyme Q10 taken by healthy patients:
A study that included 26 healthy individuals (average age, 24 years), found that coenzyme Q10 (Q10) supplementation (50 mg) had no effect on results of an electrocardiographic (ECG), which checks the heart’s electrical activity, but slightly increased systolic blood pressure (SBP) by 2 mmHg. This increase only lasted a short time. (9)
Coenzyme Q10 (CoQ10) for hypertension, dose, and monitoring requirements:
Based on a review of published studies on coenzyme Q10 (CoQ10) for hypertension researchers found that CoQ10 lowered systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg. Additionally, CoQ10 doses have increased from 34 mg/day in the early trials to 225 mg/day in the later ones. Rosenfeldt, FL et al performed a meta-analysis which noted that Co-Q10 was used to control blood pressure gradually over months by using doses of 75–360 mg daily to attain a therapeutic level of CoQ10 over >2.0 mcg/ml. Since absorption of CoQ10 varies with the preparation used and patient response varies, monitoring CoQ10 levels in the blood to guide dosage is desirable. Another factor complicating CoQ10 therapy is the use of statins which are a class of drugs used to lower cholesterol levels. Statins inhibit the synthesis of cholesterol and CoQ10 through the same mechanism. In conclusion, CoQ10 lowers blood pressure and optimal dose can be patient dependent. (10)