Andrographis paniculata and diabetes:
Andrographis paniculata and diabetes: A water solution of plant extract Andrographis paniculata (AP) was examined for blood sugar lowering effect in rats with normal and high blood sugar levels. Researchers found AP at a dose of 50 mg/kg significantly reduced blood sugar by 52.9%. No significant benefits were reported from use of any extracts in rats with normal blood sugar levels. (44)
Diabetes mellitus type 2, metformin, and vitamin B12:
The findings of a multicenter randomized controlled trial suggest that patients treated long-term with metformin, the most commonly prescribed oral drug for patients with type 2 diabetes, are at risk of developing vitamin B12 (vitB12) deficiency, and is likely to get progressively worse over time. 390 patients with type 2 diabetes received metformin (850 mg) or placebo three times daily for 4.3 years. Compared with placebo, metformin was associated with a significant 19% decrease in baseline vitamin B12 concentration. The absolute risks for vitamin B12 deficiency and low vitamin B12 level were significantly higher in the metformin group than in the placebo group: 7% and 11% higher, with numbers needed to harm of 14 and 9 per 4.3 years, respectively. Blood homocysteine levels were also significantly elevated. (45)