A safety data review of Spirulina by the Dietary Supplements Information Expert Committee (DSI-EC) of the United States Pharmacopeial Convention (USP) reported that use of Spirulina maxima and Spirulina platensis does not convey a serious health risk but addressed the following concerns with this supplement (10):
Adverse events of Spirulina have been reported by the DSI-EC, which include liver damage, nausea, diarrhea, vomiting, fatigue, headache, dizziness, itching, rash, headache, dehydration, dysphasia, renal failure, oropharyngeal pain, malaise, abdominal pain, chest pain, pyrexia, tachycardia, tachypnea, vomiting, and abdominal cramps. However, the amount, purity, and duration of Spirulina ingredients being taken were unknown and combined with other ingredients in these reports.