Coenzyme Q10, stroke volume, ejection fraction, cardiac output, cardiac index, and end-diastolic volume index in heart failure: A meta-analysis by Soja and Mortensen that included 8 double-blind placebo-controlled studies reported a significant improvement in stroke volume, ejection fraction, cardiac output, cardiac index, and end-diastolic volume index, as a result of CoQ10 supplementation. (34)
Coenzyme Q10, ejection fraction, and cardiac output: A meta-analysis of coenzyme Q10 supplementation and ejection fraction: Sander et al authored a meta-analysis of 11 studies with CoQ10 doses ranging from 60 to 200 mg/day and treatment periods ranging from 1 to 6 months. Sander et al. reported a 3.7% net improvement in the ejection fraction and an average increase in cardiac output of 0.28 l/min. (33)