Coenzyme Q10 (CoQ10)

Since CoQ10 is fat soluable, it is absorbed better with oil either in the supplement itself, or taken with food containing oil. Cardiologist, Dr. Sinatra performed his own research in which he tested 12 patients for the absorption rates of ubiquinone vs. ubiquinol. He found that ubiquinol resulted in only slightly higher levels in most of the patients tested, concluded that ubiquinol is not worth the higher cost. (39)

Coenzyme Q10 and headache prophylaxis:

Coenzyme Q10 vs. placebo and dosage for migraines:

A double-blind, placebo-controlled study demonstrated the effectiveness of Coenzyme Q10 (CoQ10) for the treatment of migraines. For a month, 42 subjects consumed a placebo, and then some of the patients were randomly assigned to receive 100 mg of a liquid, water-soluble form of CoQ10 (Q-Gel) 3 times/day (300 mg CoQ10 total) or placebo. Roughly 48% of the CoQ10 group experienced a 50% reduction in migraine attacks during the 3-month study, compared to only 14% of those taking a placebo. In addition, the patients treated with CoQ10 experienced fewer migraine attacks per month—3.2 after treatment compared to 4.4 before treatment—while the placebo group experienced no reduction in migraine frequency. CoQ10-treated subjects also experienced more headache-free days than the placebo group and fewer days with nausea. Side-effects were so minimal CoQ10 may safely be used in children and in women who may become pregnant. (1)