Coenzyme Q10 and male fertility:
In a randomized, placebo-controlled trial involving 212 infertile men with idiopathic oligoasthenoteratospermia (reduction in both sperm count and motility), supplementation with 300 mg/day coenzyme Q10 (CoQ10) for a period of 26 weeks was found to significantly improve sperm density and motility. CoQ10 is present in seminal fluid and its concentration has a direct impact on sperm count and motility. Duration of supplementation with coenzyme Q10 was positively associated with sperm count and sperm motility. In addition, mean acrosome (caplike, membrane-bound structure covering the anterior portion of the head of a sperm) reaction increased from 14% to 31% in the CoQ10 group and from 15% to only 16% in the placebo group. CoQ10 supplementation may be beneficial to certain semen parameters, but further studies are needed. (30)