Agaritine and cancer risk:
Agaritine consumption in fresh mushrooms may carry a small cancer risk. More research is needed, however mushrooms may be cooked prior to eating which removes agaritine and eliminates the possible risk.
Agaritine is a naturally compound found in mushrooms. According to research of toxicity of agaritine in transgenic mice, an estimated human consumption of 4 g/day of Swiss mushroom would be expected to contribute a lifetime cumulative cancer risk of about 2 cases per 100,000 lives. For 15 weeks, female mice were given one of 3 diets: fresh mushrooms 3 days/week followed by normal lab chow for 4 days/week (averaged daily agaritine dose 30mg/kg) or 80 mg/kg daily freeze-dried mushrooms mixed at 25% agaritine or 120 mg/kg daily of mushroom extract containing 30% agaritine . (46)