In a study on adult men, Michaëlsson K et al found that a vitamin D concentration of 24 to 34 ng/ml (60 to 85 nmol/L) approximately translates to a vitamin D dose of 2000 IU/d and corresponded to the lowest cardiovascular-related and all-cause mortality (32). Overall mortality was increased by 50–60% among a population of subjects in the lowest 10% and highest 5% of the vitamin D level curve distribution, whereas cardiovascular mortality was increased only in the bottom 10% (32). Vieth reported that the ideal level of vitamin D intake for adults should be 50 mg (2000 IU) per day (33). Bosomworth NJ conducted a review of multiple studies, and determined that 500-1500 IU/d of vitamin D reduced all-cause mortality (34).
