Diuretics, which increase the production of urine, do not effect exercise capacity except potentially in patients with congestive heart failure by relieving edema in the lungs. Heart rate during rest and exercise is not affected. Blood pressure may decrease or remain unaffected with use of diuretics.
Bronchodilators, including methylxanthines such as theophylline, sympathomimetic agents (such as ephedra, pseudoephedrine, amphetamines and methamphetamines), cromolyn sodium, and corticosteroids such as prednisone or methylprednisolone increase exercise capacity in patients with limited bronchospasm. During rest and exercise, methylxanthines and sympathomimetic agents increase or have no effect on heart rate and blood pressure. Sympathomimetic agents may also increase blood pressure during rest and exercise. Cromolyn sodium and corticosteroids have no effect on either heart rate or blood pressure during rest and exercise.