Melatonin use in patients suffering from high blood pressure:
A nightly 2.5mg melatonin supplement in 16 individuals with high blood pressure who were taking beta-blockers suggested that melatonin supplementation increases sleep quality. After 3 weeks, individuals on melatonin significantly increased total sleep time by 36 minutes, sleep efficiency by 7%, time to reach a light sleep (stage 2) decreased by14 minutes, and time spent in Stage 2 sleep increased by 41 minutes when compared to the placebo group. A significantly reduced time to reach a light sleep (-25 minutes) continued for a day after supplementation stopped suggesting the benefit of melatonin may have still been present. (91)