A systematic review of the literature on the effects of omega-3 fatty acids (n-3 FAs) (consumed as fish or fish oils rich in eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA] or as alpha-linolenic acid [ALA]) on cardiovascular disease outcomes was conducted. The authors concluded that the evidence suggests that increased consumption of n-3 FAs from fish or fish-oil supplements, but not plant derived ALA, reduces the rates of all-cause mortality, heart attack, cardiac and sudden death, and possibly stroke. The evidence for the benefits of fish oil is stronger in secondary (14 trials included)- than in primary-prevention settings (1 trial included). (6)
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