Creatine phosphate for myocardial protection:
Creatine phosphate (CP) for myocardial protection in surgery: administered to patients before undergoing coronary artery surgery had beneficial effects on the heart. Patients received either CP (n=20) or standard cardioplegic solution (control group, n=20). Three days before surgery, those in the CP group received 6 g of CP daily in two 20-min IV sessions. During surgery, standard cardioplegic solution enriched in CP (10 mmol/l) was given. After surgery 4.0 g/day of CP was administered in 2 IV injections for 2 days. Results show improved heart function after bypass surgery in patients administered CP. Ventricular arrhythmias (abnormal rapid heart rhythms) during and after surgery improved with CP. CP treatment also significantly reduced use of inotropic drugs (used to strength the heart) and damage seen in the heart muscle. (19)
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