Individuals with angina (chest pain/discomfort cause by heart problems) may benefit from use of propionyl-L-carnitine (important for energy production in cells). For 6 weeks researchers gave patients with 2 or more angina attacks per week either 500 mg L-propionylcarnitine (n=37) or placebo (n=37). Compared to placebo, L-propionylcarnitine increased the time to 0.1 mV ST-segment depression, which measures ischaemia (restriction in blood supply to tissues), and exercise duration improved by 5%. Heart rate, blood pressure and maximum exercise were not affected. (24)
Broccoli sprouts and ischemia:
Broccoli sprouts may protect against ischemia. Akhlaghi et al. administered a regular (control) diet or a diet mixed with 2% dried broccoli sprouts to rats for 10 days. At the end of the study period, the hearts of the rats were subjected to a decrease in the blood supply to tissues (ischemia) for 20 min and reperfusion (return of blood supply) for 2 hours, and evaluated for cell death, oxidative damage, and Nrf2-regulated phase 2 enzyme activities. In rats fed broccoli sprouts, markers of necrosis (premature cell death) and apoptosis (programmed cell death) was decreased by 78-86%, and indices of oxidative stress decreased by 82-116%. The results indicate that a diet with broccoli sprouts can protect the heart against oxidative stress and cell death caused by ischemia-reperfusion. (46)
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