In a study on adult men, Michaëlsson K et al found that a vitamin D concentration of 24 to 34 ng/ml (60 to 85 nmol/L) approximately translates to a vitamin D dose of 2000 IU/d and corresponded to the lowest cardiovascular-related and all-cause mortality (103). Overall mortality was increased by 50–60% among subjects in the lowest 10% and highest 5% of the vitamin D level curve distribution, whereas cardiovascular mortality was increased only in the bottom 10%. Vieth reported that the ideal level of vitamin D intake for adults should be 50 mg (2000 IU) per day (104). Bosomworth NJ conducted a review of multiple studies, and determined that 500-1500 IU/d of vitamin D reduced all-cause mortality (105). After Sun Q, et al followed 74,272 women and 44,592 men over 20 years, 9,886 cases of coronary heart disease and stroke occurred, and a 16% reduction in heart disease was seen among men with an intake of 600 IU or more per day of vitamin D, compared with those with an intake of 100 IU (106).
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