Coenzyme Q10 and acute myocardial infarction:
Treatment with coenzyme Q10 (120 mg per day) for 28 days in 73 patients (Q10 group) with acute myocardial infarction (AMI) resulted in a significant reduction in cardiac events (heart death and nonfatal heart attack) with use of coenzyme Q10. Compared to placebo, Q10 reduced cardiac events (15% vs 30.9%), chest pain that occurs when the heart is not getting enough blood (9.5 vs 28.1), irregular heartbeat (9.5% vs. 25.3%), and poor left ventricular function (8.2% vs. 22.5%). (14)
Coenzyme Q10 levels and coronary artery disease:
Yalcin et al. indicated that a relation between low plasma coenzyme Q10 (CoQ10) concentration and coronary artery disease (CAD) exists. In this study, levels of plasma CoQ10 and the ratios of CoQ10 to plasma lipids in 64 patients with CAD and 34 healthy individuals were analyzed. CoQ10 concentrations in patients with CAD and healthy individuals were found to be 0.41 and 0.77 micromol/l, respectively (p < 0.01). Additionally, compared to healthy individuals, patients with CAD had a significantly lower ratio of CoQ10 to low density lipoprotein (LDL) (p < 0.01). (15)
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