Although resveratrol inhibits platelet activation and has anti-inflammatory properties, paradoxically, it promotes atherosclerosis in hypercholesterolemic rabbits. The effects of resveratrol, a chemopreventive compound found in the skin of red grapes and in other food products, were examined on the development of atherosclerotic in rabbits fed 0.5% cholesterol. At the end of the 60-day study period, all rabbits (fed or not fed cholesterol) had similar liver function and had hypercholesterolemia or high levels of cholesterol in the blood. However, compared to the control group, resveratrol-treated rabbits had an increase in atherosclerotic lesions (p<0.002). This suggests that resveratrol results in atherosclerotic development, rather than protecting against it. (64)
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